Open Resources and Online MSc from the University of Edinburgh and RCPE

An admission to the psychiatric unit

Human brain function represented by red and blue gearsA 24 year-old woman was admitted to the a psychiatric ward with a 2 week history of thought disorder. She had become suspicious of her family, thinking they were trying to poison her. On admission her neurological examination was otherwise normal. There is no relevant family history except for an episode of depression while she was at University.

She was treated with antipsychotic agents with some response but then developed a generalised tonic-clonic seizure. Ten hours after the seizure she is confused, sweaty and tachycardic (HR 130). She exhibits waxy flexibility, a staring expression and adopts a dystonic posture of her left arm.

How would you proceed further?

Thanks to Dr David Hunt again for this week’s case.

Posted in Cases. Tags: . No Comments »

A weak hand

HandA 42 year-old man presents to his neurologist with a 8 month history of progressive weakness of the right hand.

He is otherwise well with no family history of neurological disease.

Systemic examination reveals mild gynaecomastia but is otherwise normal.

Neurological examination shows wasting of the interossei with 3/5 weakness in finer abduction and adduction. Abductor pollicis brevis is also slightly weak.

Sensory examination is normal and reflexes are reduced in the right arm. Legs and cranial nerves are normal.

How would you approach this clinical problem?

 

Thanks again to Dr David Hunt for this case.

 

 

Posted in Cases. Tags: . No Comments »

Memory loss in a 65 year old man

Memory loss patientA 65 year-old man presents with a 6 week history of memory loss which has got progressively worse. His wife has noticed that he has had a couple of episodes where he has been vacant and his face has grimaced and his arm shook.

He is otherwise well with no significant family history. He was seen by the neurology team who performed an Addenbrooke’s Cognitive Examination, and he scored 86/100. The examination was otherwise normal. Blood tests showed a mild hyponatraemia. A head CT scan is performed, which is normal.

What is the differential diagnosis?

 

There will be a mid-week case update with more clinical information for all IM students. Thanks to Dr David Hunt, Clinical Lecturer in Neurology, for the case and for moderating this week’s discussion.

Posted in Cases. Tags: . No Comments »

A discussion at the dialysis meeting

Dialysis machineMr Smith is a 50 year old man who has recently commenced hospital haemodialysis having developed end-stage renal disease secondary to ADPKD. He has an arteriovenous fistula in place and attends for four-hourly dialysis sessions on a Monday, Wednesday and Friday at his local unit.

 

His progress is discussed at the monthly dialysis unit meeting.

 

What parameters can be looked at to see if he is receiving adequate dialysis?

 

What other laboratory parameters will the dialysis team consider as part of this review?

 

There will be a mid-week update with more information on this case. Students, add your thoughts to the class discussion boards.

This is the last of the weekly cases for this teaching block, and the last of the renal cases for this year. The next case will be up on June 2nd, and we’ll be starting with a neurology case.

Posted in Cases. Tags: . No Comments »

Another visit to the transplant clinic

Heart surgery

A 53 year old teacher is seen for routine follow up in the transplant clinic. She underwent successful cadaveric renal transplantation just under two years ago having developed ESRF secondary to IgA nephropathy. She had a stormy course post-operatively with an episode of rejection in the immediate post-transplant period. She later became unwell following infection with cytomegalovirus (CMV).

 

What viral infections are of a particular concern in patients who have undergone renal transplantation and what problems can they cause?

IM students, add your thoughts to this week’s discussion board.

Posted in Cases. Tags: , . No Comments »

A discussion in the renal clinic

iStock_000018275790XSmallA 55 year old man is seen in the renal clinic following an inpatient stay. During this recent admission under the care of the renal physicians, blood tests revealed that he has advanced renal failure. The cause of his renal disease is not known, but an ultrasound scan as an inpatient showed bilateral shrunken kidneys. It was explained to the patient that he most likely has chronic kidney disease that will progress to end stage renal disease.

He briefly discussed renal replacement therapy with the team on the ward, but is coming now to see you in the renal clinic with his wife to further discuss the options.

 

How will you approach this discussion and what further information from the patient will help you counsel him about the options available?

 

IM students, please add your thoughts to the class discussion boards.

Posted in Cases. Tags: . No Comments »

Abdominal pain

Long corridor in hospital with trolly and rackA 40 year old woman with end-stage renal disease is admitted to the renal ward complaining of abdominal pain that has gradually worsened over the last 24 hours. The pain is generalised but not severe. She has passed some loose stool, but has had no vomiting.

She has undergone renal replacement therapy in the form of peritoneal dialysis for the last 18 months.

 

What other points in the history are important?

How will you proceed with investigation and initial management?

 

Students, please go to the classroom to discuss this case.

Posted in Cases. Tags: . No Comments »

Haematuria

Medical Urine SampleA 45 year old man undergoes some tests as part of a routine medical examination. He is found to have microscopic haematuria. He is surprised by this finding as he has had no symptoms. He visits his GP a week later as advised – urine dipstick again shows evidence of haematuria.

What other questions would you like to ask the patient?

How will you proceed with investigating this patient?

 

IM students, we’ll discuss the case in the classroom this week. We’ll put an update up on Tuesday, so try to get your initial thoughts posted by then.

Posted in Cases. Tags: . No Comments »

Congratulations!

Dr Eleri Williams wins the Kendell prize for teaching in Medicine 2013

Dr Eleri Williams wins the Kendell prize for teaching in Medicine 2013

Congratulations to Dr Eleri Williams, who has tonight won the Edinburgh University Students Association award for teaching in Medicine!  And thanks to Dr Can Ozkan (in the photo) and others for recommending her.  The runner-up was Dr Alwayn Leacock, who is an obstetrician in Dumfries.

Posted in Uncategorized. No Comments »

A man with a cough

Human respiratory system with lungsA 45 year old man is referred to respiratory outpatient clinic with an 8 week history of cough with yellow sputum, shortness of breath on exertion, malaise and occasional fever. He is a non-smoker. He has no respiratory background. His only past medical history is of a non-specific inflammatory arthritis for which he takes celecoxib. His only other medication is omeprazole and co-codamol. He has been on these medications for the last year and is under the care of the rheumatologists. He works as a teacher and lives with his wife and children. He has not been abroad for over 5 years. There is no history of drug or excessive alcohol use.

On examination his SpO2 is 93% on air and he is apyrexial. On auscultation of the chest there are a few scattered crackles in the midzones, but examination is otherwise unremarkable.

Blood tests are performed and show a white cell count of 12.9 x 10^9/L (neutrophil count 7.5) and CRP 65mg/ml.

 

The results of his radiological investigations are available for students to look at in the classroom.

  • Suggest one investigation that may reveal the diagnosis
  • Suggest a (differential) diagnosis and aetiology of that diagnosis

This case is again from Dr Philip Reid. Students, please discuss in the classroom.

Posted in Cases. Tags: , . No Comments »

A new TB diagnosis

CXR week 4 (1)CXR week 4 (2)A 56 year old Scottish man is referred to the respiratory outpatient clinic with a 6 week history of fever, sweats, weight loss, mild exertional dyspnoea and loss of appetite. His initial chest radiograph is shown here on the left. There is no history of foreign travel or TB contact. He has no past medical history of any relevance other than excess alcohol use.

He is brought to the ward for an induced sputum which shows a few AAFB, culture is awaited but rapid PCR probe confirms Mycobacterium Tuberculosis complex. Because of his alcohol history the consultant asks the TB specialist nurses to begin Direct Observed Therapy which is done three times a week. He is commenced on standard anti TB quadruple therapy.

 

The TB nurses report compliance with therapy. He is reviewed 4 weeks later in respiratory outpatient clinic.

He has continued to lose weight and his fevers persist. His haemoglobin and albumin have fallen further and inflammatory markers are persistently elevated. His updated chest radiograph is as shown on the right. Click on the chest radiographs to show larger images.

  • What is the explanation and how would you manage him?

Thanks again to Dr Philip Reid for this week’s case.

Posted in Cases. Tags: , . No Comments »

A woman with a urinary tract infection

CXR Resp case 3A 46 year old woman attended her General Practitioner surgery with 3 days of dysuria, frequency and nocturia. After a positive urinalysis of nitrites and leucocytes, she was diagnosed with a urinary tract infection and given a week-long course of antibiotics. She returned to her GP 5 days in to treatment with fever, myalgia, cough, and shortness of breath. It was recommended to her she continue with the antibiotics for a further 5 days.

48 hours later she arrives in the Emergency Department with escalating dyspnoea and cough. She has a low grade pyrexia, BP 110/70, RR 34, sinus tachycardia (120) and bibasal crackles. Remaining observations and examination is unremarkable.

She is found to be hypoxic. Arterial blood gas analysis (on air) shows H+ 36, pCO2 4.6, p02 7.8 and HCO3 23. Routine bloods show WCC 15.4, CRP 65, urea 7.5. A chest radiograph is obtained and shown here.

  • Interpret the CXR and describe your initial management?

The case this week comes from Dr Philip Reid.

Posted in Cases. Tags: . No Comments »